Table 2 Correlation between gene mutations* and metabolic image features†.

From: Metabolic radiogenomics in lung cancer: associations between FDG PET image features and oncogenic signaling pathway alterations

Tumor

Mutation (number of related features)

Image features (FDR value)

GLCM normalized contrast

     

ADC

PTCH2 (1)

0.029

     
 

SUVmax

SULpeak

Surface SUV SD

Entropy

GLRM short run emphasis

TFCCM inverse difference moment

SQCC

ERCC2 (1)

 

0.037

    

IRS2 (2)

0.002

 

0.049

   

NOTCH1 (2)

    

0.029

0.033

XPO1 (1)

   

0.001

  
 

NGLD small number emphasis

TFC mean convergence

    

SCLC

TSHR (1)

 

0.036

    

ROS1 (1)

0.048

     
  1. *, Consisted only of genes having mutation over 3 cases; †, consisted only of features showing significant correlation in FDR; ADC, adenocarcinoma; LN, lymph node; SQCC, squamous cell carcinoma; SCLC, small cell lung cancer; GLCM, gray level co-occurrence matrix; SUV, standardized uptake value; GLRM, gray level run-length matrix; TFCCM, texture feature coding co-occurrence matrix; NGLD, neighboring gray level dependence; TFC, texture feature coding.
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