Figure 1
From: Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum
De novo cis-polyisoprenoid biosynthesis in P. falciparum is predicted to occur in the ER. Phosphoenolpyruvate (PEP); pyruvate (PYR); glyceraldehyde 3-phosphate (G3P); 1-deoxy-D-xylulose-5-phosphate (DOXP); DOXP reductoisomerase (DXR); fosmidomycin (FOS); 2-C-methyl-D-erythritol-4-phosphate (MEP); hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP); dimethylallyl diphosphate (DMAPP); isopentenyl diphosphate (IPP); geranyl diphosphate (GPP); farnesyl diphosphate (FPP); farnesyl-geranylgeranyl diphosphate synthase (FGDPS); cis-prenyltransferase (CPT); polyprenyl diphosphate (PDP); polyprenyl diphosphate phosphatase (PPP); polyprenol reductase (PPRD); dolichol kinase (DK); dolichyl phosphate (Dol-P). The α-saturated isoprene unit of dolichol is indicated by a red circle. The figure was drawn using CorelDraw 2018 (https://www.coreldraw.com/en/).
