Table 3 Mean survival rates (in three replicates) of DKPs treated and untreated zebrafish embryos.

From: Induction of mitochondria-mediated apoptosis and suppression of tumor growth in zebrafish xenograft model by cyclic dipeptides identified from Exiguobacterium acetylicum

Concentration in μM

DKP-1

DKP-2

DKP-3

DKP-4

24 hpf

CTL

73.33 ± 0

73.33 ± 0

73.33 ± 0

73.33 ± 0

50

70.88 ± 3.44

77.77 ± 5.41

80 ± 5.96

79 ± 3.96

100

73.33 ± 5.96

82.22 ± 4.41

80 ± 5.96

82 ± 2.96

200

75 ± 5.77

75.55 ± 3.44

75.55 ± 4.12

71.55 ± 5.12

48 hpf

CTL

71.11 ± 3.44

71.11 ± 3.44

71.11 ± 3.44

68.88 ± 2.66

50

70.88 ± 5.96

80 ± 5.96

80 ± 5.96

79 ± 3.96

100

71.11 ± 1.54

80 ± 5.96

80 ± 5.96

81 ± 2.96

200

73.33 ± 3.32

75.55 ± 3.44

75.55 ± 4.12

70.34 ± 3.33

72 hpf

CTL

68.88 ± 3.44

68.88 ± 3.44

68.88 ± 3.44

68.88 ± 3.44

50

71.11 ± 3.44

68.88 ± 3.44

77.77 ± 9.10

75.51 ± 3.32

100

71.11 ± 5.55

77.33 ± 3.44

80 ± 5.96

79.3 ± 2 .77

200

68.88 ± 6.91

71.11 ± 6.88

73.33 ± 5.96

70.54 ± 3.51

96 hpf

CTL

68.88 ± 3.44

66.66 ± 3.44

68.88 ± 3.44

68.88 ± 3.44

50

66.66 ± 5.96

66.66 ± 5.96

68.88 ± 6.88

71.11 ± 2.44

100

71.11 ± 9.10

71.11 ± 9.10

80 ± 5.96

79.3 ± 2.77

200

66.66 ± 5.96

66.66 ± 5.96

69.22 ± 12

68.24 ± 5.89

  1. Data are represented as mean ± SD (n = 3). DKP-1: cyclo (l-Pro-l-Leu) (A), DKP-2: cyclo (l-Pro-l-Val) (B), DKP-3: cyclo (l-Pro-l-Phe) (C), and DKP-4: cyclo (l-Pro-l-Tyr) (D). hpf – hours post fertilization; CTL Control.