Figure 2 | Scientific Reports

Figure 2

From: Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia

Figure 2

Identification of compounds that shift transcriptional profile of Grn KO to Grn WT microglia cells. (a) 3D plot representing normalized transcriptional profiles of all conditions for three genes to demonstrate distance of radius 0.75 (light purple sphere) around the center of the WT cells. (b) Euclidian distance with compounds ranked from closest to farthest away from the WT, with KO at 0; conditions below 0 are shaded in pink. (c) Heatmap representing Grn WT, KO, and the top compound-treated 36 wells.

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