Figure 4 | Scientific Reports

Figure 4

From: Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia

Figure 4

Compounds rescue cell cycle dysregulation in Grn KO mouse microglia. (a) Hallmark GSEA analysis of upregulated genes in Grn KO microglia. (b) Cytoscape network of cell cycle genes dysregulated in Grn KO microglia. (c) Heatmap and unbiased column clustering (Ward’s method with Euclidean distance) of cell cycle genes from (b) demonstrates that compound addition to Grn KO cells normalized expression toward Grn WT cells. (d) mRNA expression of individual genes shows compound addition to Grn KO cells normalized expression toward the Grn WT cell levels. n = 2–4; *p value ≤ 0.05, **p value ≤ 0.01, ***p value ≤ 0.001.

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