Table 1 Demographics and clinical characteristics of the patients with perampanel-induced psychiatric adverse events.
From: HLAs associated with perampanel-induced psychiatric adverse effects in a Korean population
Noa | Sex | Age | Seizure type | Clinical diagnosis | Baseline seizure frequency | Epilepsy duration (yr) | Concomitant AEDs (mg/d) | Latency (months) | PER dose (mg/day) | Manifestations of PER-PAEs |
|---|---|---|---|---|---|---|---|---|---|---|
1 | F | 28 | Focal aware | PLE | 1/m | 21 | CBZ 1,100 dVPA 2,000 ZNS 300 PGB 300 CZP 1.5 | 1 | 6 | Self-injurious behavior, aggression, impulsivity, psychosis (paranoid delusion) |
2 | F | 32 | Focal impaired awareness | TLE | 1/m | 12 | LEV 1,500 ZNS 300 CLB 30 | 7 | 8 | Self-injurious behavior, impulsivity |
3 | M | 27 | Focal impaired awareness | TLE | 2/d | 27 | OXC 1,500 PGB 600 CZP 1.5 | 3 | 6 | Self-injurious behavior, labile mood, impulsivity |
4 | F | 33 | Focal impaired awareness or focal to bilateral tonic–clonic | TLE | 8/m | 20 | CBZ 1,200 LTG 300 ZNS 400 | 3 | 4 | Psychosis (undescribed delusion) |
5 | F | 36 | Focal impaired awareness or focal to bilateral tonic–clonic | TLE | 4/m | 17 | LTG 200 OXC 750 LEV 1,000 VPA 600 PB 90 CLB 10 | 2 | 6 | Psychosis (depersonalization) |
6 | F | 58 | Focal to bilateral tonic–clonic | TLE | 3/m | 17 | OXC 1,800 ZNS 200 PRM 1,000 CLB 20 | 8 | 2 | Psychosis (persecutory delusion), irritability |
7 | M | 28 | Generalized | IGE | 1/yr | 22 | CBZ 800 | 1 | 4 | Impulsivity |
8 | F | 44 | Focal impaired awareness | TLE | 2/m | 12 | ZNS 600 | 2 | 6 | Aggression, irritability |
9 | F | 34 | Focal impaired awareness or focal to bilateral tonic–clonic | TLE | 12/m | 12 | LTG 300 OXC 900 dVPA 1,600 TPM 250 PGB 150 CLB 12.5 | 4 | 8 | Aggression, irritability |
10 | F | 19 | Focal impaired awareness | TLE | 3/m | 2 | LEV 500 | 3 | 4 | Aggression |
11 | F | 40 | Focal impaired awareness | TLE | 4/m | 16 | CBZ 1,000 dVPA 250 | 1 | 4 | Aggression, irritability |
12 | M | 25 | Focal impaired awareness | TLE | 3/m | 24 | OXC 1,200 LEV 1,000 CLB 20 | < 1 | 2 | Aggression, agitation, labile mood |
13 | M | 47 | Focal impaired awareness | TLE | 4/m | 22 | OXC 1,800 LEV 2,000 PB 180 CLB 10 | 1 | 6 | Aggression, agitation, loss of interest |
14 | M | 65 | Focal to bilateral tonic–clonic | TLE | 6/yr | 3 | RFM 200 | < 1 | 4 | Aggression, labile mood |
15 | M | 29 | Focal impaired awareness or focal to bilateral tonic–clonic | FLE | 10/m | 18 | VPA 1,500 LEV 1,000 | 5 | 8 | Aggression |
16 | F | 25 | Focal impaired awareness | TLE | 3/d | 18 | PHT 200 LEV 2,000 TPM 400 CLB 10 | 3 | 4 | Aggression |
17 | M | 43 | Focal to bilateral tonic–clonic | FLE | 4/yr | 36 | OXC 1,200 dVPA 1,750 | 1 | 4 | Aggression |
