Figure 5 | Scientific Reports

Figure 5

From: Effects of empagliflozin and target-organ damage in a novel rodent model of heart failure induced by combined hypertension and diabetes

Figure 5

Protein expression after empa treatment. (A) Representative image of ED-1 IHC staining for macrophages in the heart from empa and vehicle-treated rats. The number of macrophages was decreased in the heart of empa treated rats. (B) Representative image of fibronectin IHC staining in the hearts from empa and vehicle-treated rats. Interstitial cardiac fibrosis was estimated as fibronectin-positive area per view field. Heart sections of empa and vehicle-treated rats showed no differences in cardiac interstitial fibrosis. (C) Representative image of collagen I IHC staining in the hearts from empa and vehicle-treated rats. Perivascular fibrosis area was normalized to vessel media cross-sectional area. Heart sections of empa and vehicle-treated rats showed no differences in cardiac perivascular fibrosis. Students t-test, *** p < 0.001; data expressed as mean ± SEM.

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