Table 3 The PRS effect on the risk of developing type 2 diabetes.

From: High genetic burden of type 2 diabetes can promote the high prevalence of disease: a longitudinal cohort study in Iran

Quintile

Sample size

Age, sex and BMI-adjusted model

Full model

HR (95% CI)

p-value

HR (95% CI)

p-value

2 (20–40%)

767

0.9 (0.6, 1.2)

0.53

0.93 (0.6, 1.3)

0.7

3 (40–60%)

726

1.35 (1, 1.8)

0.04

1.32 (0.96, 1.8)

0.08

4 (60–80%)

902

1.5 (1.1, 2)

0.003

1.45 (1.07, 1.9)

0.01

5 (> 80%)

825

1.96 (1.4, 2.5)

0.00001

1.72 (1.2, 2.3)

0. 001

  1. Hazard ratio (HR) with 95% confidence intervals (95% CI) from Cox regression analysis. The full model is adjusted for age, sex, BMI, fasting plasma glucose, 2-h plasma glucose, cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels. The first quintile (< 20%) containing 783 individuals were considered as reference. The whole sample size was 4,003 individuals.
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