Figure 4 | Scientific Reports

Figure 4

From: A biphasic nanohydroxyapatite/calcium sulphate carrier containing Rifampicin and Isoniazid for local delivery gives sustained and effective antibiotic release and prevents biofilm formation

Figure 4

Kirby-Bauer (KB) disk diffusion assay. Agar diffusion assay of calcium sulphate hemihydrate (CSH)/nanohydroxyapatite (nHAP) based nanocement (NC) and drug loaded NC (drug@NC) showing anti-mycobacterial (Mycobacterium smegmatis) activity of pristine released RFP and INH as indicated by increased zone of inhibition (ZOI) surrounding drug@NC. Digital picture of NC loaded with increasing concentration of (a) INH (1%, 1.65%, 5% & 10%). (b) RFP (1%, 3.3%, 5% & 10%) and (c) RFP + INH (1% + 1%, 3.3% + 1.65%, 5% + 5% & 10% + 10%). Quantification of ZOI using digital Vernier calliper in NC loaded with increasing concentration of (d) INH, (e) RFP, (f) RFP + INH. *p < 0.05, **p < 0.01, ***p < 0.001.

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