Table 1 Characteristics of families carrying the BRCA2 c.9227G>T.
Family ID | Number of breast cancer cases (age) | Number of ovarian cancer cases (age) | Number of breast cancer phenocopies (age) | Other tumors (age) | BOADICEA | Number of other tested family members | LRa |
|---|---|---|---|---|---|---|---|
33 | 6 (50, 44, 32/40b, 30, 52, 41) | – | – | Kidney (65) | 92.2 | 1 | 3.44 |
72 | 4 (42/46b, 53, 59, 33) | – | 1 (60) | – | 71.2 | 1 | 1.17 |
139/2102 | 3 (47, 47, 48) | 1 (66) | – | Central nervous system (53) | 3.9 | 2 | 3.7 |
219 | 5 (44, 37, 50c, 50, 65) | 1 (57c) | 1 (55/55b) | Kidney (63), lung (66) | 52.9 | 3 | 10.77 |
716 | 2 (59c, 24) | 1 (53c) | – | – | 73.3 | 3 | 1.03 |
873/987 | 6 (50, 44, 25, 49/58b, 33, 81) | 2 (59, 63) | 1 (55)d | – | 93.2 | 8 | 40.61 |
1339 | 2 (40, 44) | – | – | – | 3.6 | 1 | 1.87 |
1579 | 2 (31, 56) | – | – | Ampulla of Vater (60) | 10.4 | 4 | 3.16 |
2535 | 3 (45, 45/78b, 43) | – | – | – | 20.0 | – | – |
2848 | 2 (37, 46) | 1 (62) | 1 (42) | – | 31.5 | 1 | 1.13 |
3336 | 3 (43c, 60, 46) | 1 (55c) | – | Kidney (61), prostate (75) | 33.0 | 1 | 1.82 |
3816 | 2 (55/70b, 50) | 1 (68) | – | – | 19.0 | – | – |
4196 | 1 (43) | 1 (66) | – | Prostate (44), thyroid (64) | 8.4 | – | – |
4482 | 2 (35, 40) | – | – | Pancreas (63) | 7.6 | – | – |
5405 | 1 (65) | 1 (47) | – | – | 2.9 | – | – |
