Figure 3

Effect of circulating prothrombin levels on clot size: For a brief description of the events leading to a blood clot in Panels (A–E), see Fig. 2. Panels (C, D) Initial values of prothrombin influence the size of the thrombin peak. This results in blood clot size dependence on the initial prothrombin level. Prothrombin levels in blood vary person-to-person and the risk of blood clot formation may depend accordingly²⁰. Model (1) may provide the ability to quantify these differences in severity and subsequent risk. Panel (E) Resulting blood clot sizes due to varying circulating prothrombin levels. As initial prothrombin level increases, resultant blood clot size increases. As a result, model (1) may be used to quantify the role of prothrombin in determining blood clot severity.