Figure 4 | Scientific Reports

Figure 4

From: Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance

Figure 4

Effect of combination treatments on prostate cancer spheroids. (A) Cells were plated on Matrigel-coated 24 well plates. Six drugs (cabozantinib, clofarabine, vinblastine, idarubicin, omacetaxine and sorafenib) were tested on prostate cancer spheroids. These experiments were performed in triplicate and are average of 3 replicates from 3 different wells of a cell culture plate. The pictures are representative images as acquired using an EVOS cell imager. (B) Proliferation of spheroids treated with cabozantinib (CBZ), clofarabine (CFB), vinblastine (VBT), idarubicin (IRB), omacetaxine (OAT) and sorafenib (SRN) measured using AnnexinV/PI staining.

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