Figure 2
From: Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia
Loss of Innervation Induces Transcriptional Changes. (a) Differentially up- and down-regulated genes at each day relative to sham. Grey-scale colors represent which day the gene was initially significantly differentially regulated. (b) Venn diagram showing overlap of differentially regulated genes at each time point relative to sham. (c) Upstream regulator of gene expression changes determined using Ingenuity Pathway Analysis. (d) Significant enrichment of Mef2 isoform target genes beginning at 2–4 days relative to sham. All mice were male (n = 4 per time point). ANKRD1—Ankyrin Repeat Domain 1; ATF4—Activating Transcription Factor 4; CDKN1A—Cyclin Dependent Kinase Inhibitor 1A; CSRP3—Cysteine And Glycine Rich Protein 3; GADD45A—Growth Arrest and DNA Damage Inducible Alpha; Mef2—Myocyte Enhancer Factor 2; PEG3—Paternally Expressed 3; Six2—SIX Homeobox 2.
