Table 1 Comparison of characteristics of sepsis and septic shock patients according to 28-day mortality.

From: Diagnosis and mortality prediction of sepsis via lysophosphatidylcholine 16:0 measured by MALDI-TOF MS

 

All patients (N = 113)

Survivors (N = 73)

Non-survivors (N = 40)

P-value

Variables

Age (years), median, [IQR]

70 [60.5–77.5]

70 [58.8–77.2]

69 [61–78]

0.989

Gender, male, N (%)

70 (61.9)

44 (60.3)

26 (65.0)

0.479

BMI (kg/m2)

21.8 [19.2–25.1]

22.3 [18.8–25.3]

21.4 [19.3–24.4]

0.501

Site of infection, N (%)

Pulmonary

65 (57.5)

43 (58.9)

22 (55.0)

0.676

Urinary tract

15 (13.3)

14 (19.2)

1 (2.5)

0.018

Abdomena

21 (18.6)

8 (11.0)

13 (32.5)

0.006

Skin and soft tissue

5 (4.4)

3 (4.1)

2 (5.0)

1.0*

Othersb

7 (6.2)

5 (6.8)

2 (5.0)

1.0*

Charlson comorbidity index

5 (4–7)

5 (4–6)

5 (4–8)

0.061

Major comorbidities

Malignancy

29 (25.7)

16 (21.9)

13 (32.5)

0.079

DM

46 (40.7)

28 (38.4)

18 (45.0)

0.158

CKD or ESRD

30 (26.5)

18 (24.7)

12 (30.0)

0.262

CHF

13 (11.5)

7 (9.6)

6 (15.0)

0.339*

Clinical parameters

Sepsis

41 (36.3)

29 (39.7)

12 (30.0)

0.149

Septic shock

72 (63.7)

44 (60.3)

28 (70.0)

0.149

Bacteremia

36 (31.9)

23 (31.5)

13 (32.5)

0.663

Mechanical ventilation

65 (57.5)

34 (46.6)

31 (77.5)

0.003

CRRT

41 (36.3)

20 (27.4)

21 (52.5)

0.002

Clinical severity score, D0

APACHE II score

26 [19–32.5]

23 [16–32]

31 [23–35]

0.001

SOFA score

8 [7–11]

8 [6–10]

9 [8–13]

0.003

Laboratory parameters, D0

Leukocytes (× 106/mL)

13.7 [7.1–19.2]

13.2 [7.7–19.0)

14.1 [6.1–19.5]

0.783

Platelets (× 106/mL)

144 [78.5–239]

160 [87.3–239.0]

132 [45–239]

0.305

CRP (mg/L)

171.7 [89.7–281.2]

212.2 [116.8–288.6]

158.9 [72.5–217.9]

0.034

Procalcitonin (ng/mL)

4.1 [1.1–26.6]

3.7 [0.9–29.6]

5.6 [1.7–21.4]

0.755

Lactate (mmol/L)

2.3 [1.6–4.6]

2.1 [1.5–3.2]

3 [1.9–8.9]

0.002

Albumin (g/dL)

2.5 [2.1–2.8]

2.6 [2.1–2.8]

2.4 [2.1–2.8]

0.072

Total Bilirubin (mg/dL)

0.6 [0.3–1.2]

0.6 [0.3–0.9]

0.7 [0.4–2.0]

0.079

BUN (mg/dL)

32.8 [20.0–50.8]

30.4 [19.9–49.3]

34.8 [23.4–52.6]

0.329

Creatinine (mg/dL)

1.7 [0.8–2.8]

1.4 [0.7–2.8]

2.1 [0.9–3.0]

0.19

  1. BMI body mass index, DM diabetes mellitus, CKD chronic kidney disease, ESRD end stage renal disease, CHF congestive heart failure, CRRT continuous renal replacement therapy, APACHE Acute Physiology and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, CRP C-reactive protein, BUN Blood urea nitrogen, ABGA arterial blood gas analysis.
  2. Values are expressed as n (%) or median [interquartile range] unless otherwise indicated.
  3. *Fisher exact test.
  4. aAbdomen: gastrointestinal and hepatobiliary infection, peritonitis.
  5. bOthers: meningitis, spinal abscess, septic arthritis, primary unknown infection.
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