Table 2 Cox proportional hazard model of 28-day mortality.

From: Diagnosis and mortality prediction of sepsis via lysophosphatidylcholine 16:0 measured by MALDI-TOF MS

Variable

Univariable analysis

Multivariable analysis

HR

95% CI

P-value

Adjusted HR

95% CI

P-value

Age (year)

1.001

0.974–1.028

0.967

   

Sex (male)

1.356

0.583–3.155

0.480

   

BMI (kg/m2)

1.008

0.928–1.095

0.843

   

Charlson comorbidity index

1.196

1.010–1.417

0.038

1.269

0.958–1.681

0.097

Site of infection

Pulmonary

1

  

1

  

Urinary tract

0.154

0.019–1.259

0.081

0.213

0.014–3.291

0.268

Abdomena

3.391

1.137–10.112

0.028

9.074

1.443–57.073

0.019

Skin and soft tissue

1.439

0.222–9.335

0.703

10.469

0.680–161.090

0.092

Othersb

0.863

0.153–4.858

0.867

0.001

0.000–5.119

0.999

Septic shock

1.926

0.786–4.719

0.152

   

Mechanical ventilation

3.784

1.511–9.476

0.003

12.415

2.113–72.947

0.005

CRRT

3.750

1.599–8.793

0.002

4.236

1.029–17.435

0.046

Bacteremia

1.208

0.517–2.819

0.663

   

Lactate

1.388

1.163–1.658

< 0.001

1.455

1.035–2.045

0.031

Procalcitonin

0.993

0.980–1.007

0.347

   

Δ LPC16:0 (D1–D0) ≤ 7.288

4.778

1.878–12.155

< 0.001

6.491

1.614–26.100

0.008

  1. HR hazard ratio, CI confidence interval, BMI body mass index, CRRT continuous renal replacement therapy, SOFA Sequential Organ Failure Assessment, APACHE Acute Physiology and Chronic Health Evaluation.
  2. aAbdomen: gastrointestinal, hepatobiliary infection, peritonitis.
  3. bOthers: meningitis, spinal abscess, septic arthritis, primary unknown infection.
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