Figure 3

The frequency spectra of amino-acid mutations in 2,492 SARS-CoV-2 complete genome sequences, and its impact on mortality rates. Amino-acid (aa) mutations found in the open reading frames (ORFs) of the SARS-CoV-2 genomes according to (a) geographic areas and (b) different climate zones. We found six core shared mutations (at residue position of R203K, G204R, G251V, L3606F, P4714L, D614G) in Asia, Europe, Africa, Australia, North America, and South America, and four core shared mutations (at residue position of Q57H, D614G, L3606F, and P4714L) in continental, diverse, dry, tropical and temperate conditions. In both cases (a and b), yellow circles represent frequency of aa substitutions shared by all categories, and the frequency of aa substitutions shared by at least two continents/climate zones are shown in green circle, while the pink colored ribbons indicate unique aa mutations in each individual regional and climate zone. (c) Estimated case fatality rates of SARS-CoV infections in 45 countries of the globe according to climatic variations. Numbers in parentheses indicate total confirmed cases/total deaths according to the World Health Organization (WHO) as of 30th March, 2020. Organization (WHO) as of 30th March, 2020. Data were finally visualized using custom Venn diagrams online tool (https://bioinformatics.psb.ugent.be/webtools/Venn/) along with illustrator CC 2019 trial version.