Table 1 Demographic and virological-immunological features of non-transferred and transferred patients in the Madrid cohort at the end of December 2017.

From: Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017)

Demographic characteristics

Non-transferreda (N = 106)

Transferredb (N = 184)

P value

Female, No. (%)

61 (57.5)

106 (57.6)

1.0000

Route of infection, No. (%)

Perinatally

93 (87.7)

173 (94)

0.0766

Transfusion

2 (1.9)

6 (3.3)

0.7148

Sexual

2 (1.9)

3 (1.6)

1.0000

Unknown

9 (8.5)

2 (1.1)

0.0024

Age, years, mean [SD], No. (%)

15.6 [5.7]

27 [4.2]

< 0.0001

0 to < 6

7 (6.6)

0

0.0008

6 to < 12

22 (20.8)

0

< 0.0001

12 to < 18

40 (37.7)

3 (1.6)

< 0.0001

18 to < 24

31 (29.2)

44 (23.9)

0.3187

24 to ≤ 30

6 (5.7)

93 (50.6)

< 0.0001

> 30

0

44 (23.9)

< 0.0001

Period of HIV diagnosis, No. (%)

1985–1989

0

30 (16.3)

< 0.0001

1990–1994

4 (3.8)

88 (47.8)

< 0.0001

1995–1999

23 (21.7)

49 (26.6)

0.3491

2000–2004

28 (26.4)

12 (6.5)

< 0.0001

2005–2009

20 (18.9)

1 (0.6)

< 0.0001

2010–2014

20 (18.9)

3 (1.6)

< 0.0001

2015–2016

10 (9.4)

1 (0.6)

< 0.0001

Unknown

1 (0.9)

0

0.3655

Age at diagnosis, years, median [IQR], No. (%)

0.6 [0.2–4.6]

1.3 [0.4–4.6]

0.0742

0 to < 6

86 (81.2)

149 (81.0)

1.0000

6 to < 12

14 (13.2)

27 (14.7)

0.8614

12 to ≤ 18

5 (4.7)

8 (4.3)

1.0000

Unknown

1 (0.9)

0

0.3655

Calendar year of transfer, No. (%)

1997–1999

–

4 (2.2)

 

2000–2002

–

9 (4.9)

 

2003–2005

–

21 (11.4)

 

2006–2008

–

29 (15.8)

 

2009–2011

–

47 (25.5)

 

2012–2014

–

42 (22.8)

 

2015–2017

–

30 (16.3)

 

Unknown

–

2 (1.1)

 

Age at transfer, years, median [IQR]

–

18.7 [17.6–20.8]

 

Origin of birthc, No. (%)

Spain (West Europe)

73 (68.9)

171 (92.9)

< 0.0001

Portugal (West Europe)

0

1 (0.5)

1.0000

East Europe

0

1 (0.5)

1.0000

North Africa

2 (1.9)

2 (1.1)

0.6249

Sub-Saharan Africa

19 (17.9)

2 (1.1)

< 0.0001

South and Central America

10 (9.4)

7 (3.8)

< 0.0001

Asia

2 (1.9)

0

0.1328

Virological featuresd No. (%)

Non-transferred

N = 75 (70.7)

Transferred

N = 133 (72.3)

P value

Viral load, median [IQR], No. (%)

35 [20–37]

37 [20–71]

0.0441

≤ 20

28 (37.3)

43 (32.3)

0.5427

21–50

25 (33.4)

44 (33.1)

1.0000

51–200

4 (5.3)

18 (13.5)

0.0983

201–500

1 (1.3)

5 (3.7)

0.4220

501–1,000

3 (4.0)

2 (1.5)

0.3536

1,001–10,000

3 (4.0)

9 (6.8)

0.5429

> 10,000

3 (4.0)

11 (8.3)

0.3876

Unknown

8 (10.7)

1 (0.8)

0.0014

CD4 percentage, mean [SD], No. (%)

33.3% [9.2]

31.6% [11.4]

0.2715

< 25%

11 (14.7)

35 (26.3)

0.0571

25–50%

55 (73.3)

90 (67.7)

0.4346

> 50%

1 (1.3)

7 (5.3)

0.2631

Unknown

8 (10.7)

1 (0.8)

0.2715

CD4 cells/mm3, median [IQR], No. (%)

781 [561–962]

725 [498–901]

0.279

≤ 200

2 (2.6)

7 (5.3)

0.4934

201–350

4 (5.3)

8 (6.0)

1.0000

351–500

8 (10.7)

19 (14.3)

0.5244

501–1,000

39 (52.0)

74 (55.7)

0.6646

1,001–1,500

11 (14.7)

22 (16.5)

0.8440

> 1,500

3 (4.0)

2 (1.5)

0.3536

Unknown

8 (10.7)

1 (0.8)

0.0014

Nadir CD4 percentage, median [IQR], No. (%)

15% [11–22.7]

11% [3–16.7]

0.0001

< 15%

33 (44.0)

88 (66.2)

0.0022

15–24%

22 (29.3)

36 (27.0)

0.7492

≥ 25%

12 (16.0)

8 (6.0)

0.0265

Unknown

8 (10.7)

1 (0.8)

0.0014

Nadir CD4 (cells/mm3), median [IQR], No. (%)

379 [206–500]

187 [41.2–345.5]

< 0.0001

< 200

15 (20.0)

67 (50.4)

< 0.0001

200–499

35 (46.6)

57 (42.8)

0.6632

≥ 500

17 (22.7)

8 (6.0)

0.0007

Unknown

8 (10.7)

1 (0.8)

0.0014

CD8 percentage, median [IQR], No. (%)

36% [28–42]

39.6% [34–53]

0.0004

< 25%

11 (14.6)

4 (3.0)

0.0036

25–50%

48 (64.0)

92 (69.2)

0.4466

> 50%

8 (10.7)

36 (27.0)

0.0049

Unknown

8 (10.7)

1 (0.8)

0.0014

CD8 cells/mm3, median [IQR], No. (%)

795 [552–1077]

873 [701–1210]

0.0232

≤ 200

1 (1.3)

1 (0.8)

1.0000

201–350

3 (4.0)

3 (2.2)

0.6694

351–500

7 (9.3)

7 (5.2)

0.2651

501–1,000

37 (49.4)

69 (51.9)

0.7735

1,001–1,500

16 (21.3)

37 (27.8)

0.3251

> 1,500

3 (4.0)

15 (11.3)

0.1208

Unknown

8 (10.7)

1 (0.8)

0.0014

CD4/CD8 ratio [IQR], No. (%)

0.9 [0.6–2.3]

0.8 [0.4–1.2]

0.0205

< 1

34 (45.3)

82 (61.6)

0.0291

≥ 1

33 (44.0)

50 (37.6)

0.0849

Unknown

8 (10.7)

1 (0.8)

0.0014

  1. aPatients from Madrid Cohort of HIV-1 infected children and adolescents under follow-up in pediatric units.
  2. bTransferred from pediatric to adult units.
  3. cBirth origin of patients by country: Portugal (n = 1), Romania (n = 1), Morocco (n = 4), Cameroon (n = 1), Equatorial Guinea (n = 15), Mozambique (n = 1), Nigeria (n = 4), Argentina (n = 1), Bolivia (n = 2), Colombia (n = 2), Ecuador (n = 4), Guatemala (n = 1), Haiti (n = 1), Honduras (n = 3), Mexico (n = 1), Peru (n = 1), Dominican Republic (n = 1), China (n = 1), and India (n = 1).
  4. dVirological features in patients with resistance information. Viral Load: HIV-1 RNA-copies/ml. In bold, significant p values (< 0.05).
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