Figure 5 | Scientific Reports

Figure 5

From: Transcriptomics uncovers substantial variability associated with alterations in manufacturing processes of macrophage cell therapy products

Figure 5

Regulatory macrophage specific genes. (a) Stepwise Venn diagram analysis of genes upregulated in Mreg and Mreg_UKR in comparison to other macrophages and PCMO-like cells. Shared gene subset defines regulatory macrophage-specific genes, unique gene subsets define genes specific for each cell type. Heatmap visualization of genes (b) common between Mreg and Mreg_UKR; (c) specific for Mreg only; (d) specific for Mreg_UKR only. Genes encoding membrane-localized proteins (GO:0005886: plasma membrane and/or GO:0016021: integral component of membrane) are marked with black stars. Green stars indicate transcription factors and blue stars—transcription co-factors.

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