Table 4 Biodistribution data up to 2 h after injection of 18–20 MBq of 99mTc in healthy male rats.
Time, h | Stomach | Liver | Spleen | Blood | Heart | Lungs | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
% | %/g | % | %/g | % | %/g | %/ml | % | %/g | % | %/g | |
99mTc-Al2O3 | |||||||||||
1 | 1.3 ± 0.2 | 0.48 ± 0.1 | 6.6 ± 0.3 | 0.55 ± 0.2 | 1.3 ± 0.2 | 0.65 ± 0.1 | 0.2 ± 0.1 | 0.3 ± 0.1 | 0.25 ± 0.09 | 0.6 ± 0.1 | 0.22 ± 0.09 |
2 | 1.7 ± 0.2 | 0.61 ± 0.15 | 10.5 ± 0.9 | 0.87 ± 0.21 | 2.1 ± 0.3 | 1.1 ± 0.15 | 0.24 ± 0.04 | 0.3 ± 0.06 | 0.24 ± 0.008 | 0.6 ± 0.12 | 0.22 ± 0.1 |
3 | 1.8 ± 0.4 | 0.62 ± 0.22 | 13.5 ± 2.07 | 1.15 ± 0.24 | 2.8 ± 0.5 | 1.4 ± 0.14 | 0.21 ± 0.03 | 0.4 ± 0.09 | 0.25 ± 0.008 | 0.51 ± 0.15 | 0.23 ± 0.08 |
5 | 1.8 ± 0.7 | 0.63 ± 0.31 | 17.3 ± 1.9 | 1.35 ± 0.31 | 3.5 ± 0.7 | 1.65 ± 0.2 | 0.27 ± 0.07 | 0.3 ± 0.11 | 0.29 ± 0.06 | 0.59 ± 0.14 | 0.31 ± 0.06 |
24 | 2.4 ± 0.4 | 0.87 ± 0.38 | 18.3 ± 1.4 | 1.52 ± 0.29 | 3.6 ± 0.6 | 1.80 ± 0.2 | 0.3 ± 0.1 | 0.4 ± 0.15 | 0.23 ± 0.01 | 0.54 ± 0.2 | 0.20 ± 0.1 |
99mTc-DTPAmod | |||||||||||
1 | 1.2 ± 0.2 | 0.48 ± 0.1 | 6.6 ± 0.3 | 0.55 ± 0.2 | 1.3 ± 0.2 | 0.65 ± 0.1 | 0.2 ± 0.1 | 0.3 ± 0.1 | 0.25 ± 0.09 | 0.6 ± 0.1 | 0.22 ± 0.09 |
2 | 1.5 ± 0.2 | 0.60 ± 0.15 | 10.5 ± 0.9 | 0.87 ± 0.21 | 2.1 ± 0.3 | 1.1 ± 0.15 | 0.24 ± 0.04 | 0.3 ± 0.06 | 0.24 ± 0.008 | 0.6 ± 0.12 | 0.22 ± 0.1 |
3 | 1.5 ± 0.4 | 0.62 ± 0.22 | 13.9 ± 2.07 | 1.15 ± 0.24 | 2.8 ± 0.5 | 1.4 ± 0.14 | 0.27 ± 0.03 | 0.31 ± 0.09 | 0.25 ± 0.008 | 0.61 ± 0.15 | 0.23 ± 0.08 |
5 | 1.5 ± 0.7 | 0.63 ± 0.31 | 16.3 ± 1.9 | 1.35 ± 0.31 | 3.3 ± 0.7 | 1.65 ± 0.2 | 0.27 ± 0.07 | 0.3 ± 0.11 | 0.24 ± 0.06 | 0.59 ± 0.14 | 0.21 ± 0.06 |
24 | 2.2 ± 0.4 | 0.88 ± 0.38 | 18.3 ± 1.4 | 1.52 ± 0.29 | 3.6 ± 0.6 | 1.80 ± 0.2 | 0.3 ± 0.1 | 0.4 ± 0.15 | 0.23 ± 0.01 | 0.54 ± 0.2 | 0.20 ± 0.1 |
99mTc-Fe@C | |||||||||||
1 | 1.1 ± 0.2 | 0.48 ± 0.1 | 6.6 ± 0.3 | 0.55 ± 0.2 | 1.3 ± 0.2 | 0.65 ± 0.1 | 0.2 ± 0.1 | 0.3 ± 0.1 | 0.25 ± 0.09 | 0.6 ± 0.1 | 0.22 ± 0.09 |
2 | 1.6 ± 0.2 | 0.60 ± 0.15 | 10.5 ± 0.9 | 0.81 ± 0.21 | 2.2 ± 0.3 | 1.1 ± 0.15 | 0.24 ± 0.04 | 0.3 ± 0.06 | 0.24 ± 0.008 | 0.6 ± 0.12 | 0.22 ± 0.1 |
3 | 1.4 ± 0.4 | 0.62 ± 0.22 | 13.9 ± 2.07 | 1.15 ± 0.24 | 2.8 ± 0.5 | 1.6 ± 0.14 | 0.27 ± 0.03 | 0.31 ± 0.09 | 0.25 ± 0.008 | 0.61 ± 0.15 | 0.25 ± 0.08 |
5 | 1.7 ± 0.7 | 0.63 ± 0.31 | 15.3 ± 1.9 | 1.35 ± 0.31 | 3.3 ± 0.7 | 1.65 ± 0.2 | 0.27 ± 0.07 | 0.3 ± 0.11 | 0.24 ± 0.06 | 0.59 ± 0.14 | 0.21 ± 0.06 |
24 | 2.6 ± 0.4 | 0.88 ± 0.38 | 18.7 ± 1.4 | 1.52 ± 0.29 | 3.6 ± 0.6 | 1.80 ± 0.2 | 0.4 ± 0.1 | 0.6 ± 0.15 | 0.23 ± 0.01 | 0.54 ± 0.2 | 0.20 ± 0.1 |
