Figure 5
In vivo tumor growth results. Comparison study in the subcutaneously injected mice melanoma model. The treatment was started on the 10th day after inoculation. (A) The tumor growth curves show a significant difference between the control and treated groups from the fifth day of treatment (Mean ± SD). (B) At the end of the study, the mean tumor volume in the treated groups was more than 50% less than that of the control group. There was no significant difference between the efficacy of whole FWGE and A250 (Mean ± SEM). (C) The Kaplan–Meier survival curve shows a more than 50% increase in median OS in the treated group. (D) The daily dose of A250 was calculated from the isolation yield, and thus it was administered at a 33-fold lower dose than that of whole FWGE (one-way ANOVA, **p < 0.05, ***p < 0.001, ****p < 0.0001). Graphpad Prism 5.02 software was used for data analysis.
