Table 3 The kinetic constant (K), correlation coefficient (R2) and Release exponent (n) of kinetic data analysis of drug released from the various PLGA-PEG microspheres formulations.

From: Drug-encapsulated blend of PLGA-PEG microspheres: in vitro and in vivo study of the effects of localized/targeted drug delivery on the treatment of triple-negative breast cancer

Formulations

Temperature (°C)

Zero order

First order

Higuchi model

Koresmeyer–Peppas

K

R2

K

R2

K

R2

K

R2

n

PLGA-PEG_PGS

37

1.232

0.711

0.014

0.505

12.786

0.857

1.920

0.973

0.870

PLGA-PEG_PGS-LHRH

1.226

0.749

0.015

0.529

12.578

0.882

1.837

0.977

0.889

PLGA-PEG_PTX

0.769

0.692

0.008

0.330

8.137

0.867

3.271

0.962

0.459

PLGA-PEG_PTX-LHRH

0.680

0.704

0.007

0.294

7.802

0.845

3.340

0.848

0.490

PLGA-PEG_PGS

41

1.315

0.752

0.014

0.513

13.533

0.875

1.982

0.969

0.855

PLGA-PEG_PGS-LHRH

1.236

0.760

0.015

0.548

12.607

0.884

1.785

0.976

0.885

PLGA-PEG_PTX

0.853

0.718

0.009

0.354

8.964

0.886

3.398

0.969

0.447

PLGA-PEG_PTX-LHRH

0.685

0.672

0.007

0.288

7.316

0.856

3.431

0.912

0.446

PLGA-PEG_PGS

44

1.371

0.757

0.014

0.519

13.987

0.867

2.034

0.953

0.842

PLGA-PEG_PGS-LHRH

1.281

0.749

0.015

0.551

13.085

0.873

1.809

0.966

0.881

PLGA-PEG_PTX

0.881

0.728

0.009

0.357

9.224

0.951

3.210

0.985

0.490

PLGA-PEG_PTX-LHRH

0.753

0.712

0.008

0.311

7.939

0.885

3.302

0.968

0.450

Back to article page