Figure 4
ST-2262 increases withdrawal latency and reduces thermal evoked heart rate increase in a non-human primate noxious heat model. (A,B) Individual subject data points showing changes in withdrawal latency (A) and transient change in heart rate (ΔHR) (B) following thermal stimuli. Bar graphs are expressed as mean ± SEM. **Dunnett’s multiple comparison test, compared to baseline, p < 0.01. (C) Plasma level concentration of ST-2262 in plasma at different doses. (D,E) A lower heating rate thermal stimulus was presented for a maximum of 20 s, which selectively activates C fibers47. In two subjects, the C-fiber-induced hand withdrawal response was replicable for testing. The efficacy endpoints measured were withdrawal latency (A) and heart rate change (B).
