Figure 4

Change in average Mutated Allele Frequencies (MAF) at different time points. Average and SEM of MAFs at each time point for all variants tested (A) and for the 87 variants detected at baseline time point T0 (B). Average MAFs for all variants tested in patients with pCR (C) and non pCR (D). Only tested variants are considered at each time point and non-detectable values are assigned a “0” value.