Figure 4
Cross-classification by BMI, ABSI and either smoking status, physical activity, age or attained education. Hazard ratios (points) with 95% confidence intervals (segments)—derived from delayed-entry Cox proportional hazards models, including a cross-classification variable for ABSI-by-BMI-by-factor category (with the “factor” being either smoking status, physical activity, age at recruitment or attained education) and adjustment for smoking status and intensity (omitted for “factor” smoking status), alcohol intake, attained education level (omitted for “factor” attained education), physical activity (omitted for “factor” physical activity) and height and stratified for age at recruitment (omitted for “factor” age) and study centre (for the categorisation of covariates see Supplementary Table S2 online); white points—low-ABSI subgroup: A Body Shape Index (ABSI) < 83.3 for men and < 76.2 for women; dark points—high-ABSI subgroup: ABSI ≥ 83.3 for men and ≥ 76.2 for women; BMI category—body mass index (BMI) category according to the World Health Organisation classification: 25 (18.5 to < 25 kg/m2), 30 (25 to < 30 kg/m2), 35 (30 to < 35 kg/m2); pinteract—p value for statistical interaction on a multiplicative scale, derived from a likelihood ratio test comparing a model including the cross-classification ABSI-by-BMI-by-factor variable with a model including separate variables for ABSI-by-BMI (ten categories) and factor (three categories); p values—derived from comparisons of high-ABSI with low-ABSI subgroups within each BMI category: ***p < 0.0001, **p < 0.001, *p < 0.01, + (“plus”) p < 0.05, ~ (“tilda”) p < 0.1,—(“minus”) p ≥ 0.1; hazard ratios (95% confidence intervals) for the latter comparisons are shown in Supplementary Table S4 online.
