Figure 1
From: Systems-level differential gene expression analysis reveals new genetic variants of oral cancer

Normalization and differential analysis. Histogram (smoothed histograms) shows density estimate of the data. Typically, the distributions of the arrays have similar shapes and ranges. Arrays whose distributions are very different from the others are considered for possible problems. High levels of background shifted an array's distribution to the right. Lack of signal diminishes its right tail. A bulge at the upper end of the intensity range indicated the signal saturation.