Figure 6

Analysis and exploration of mutations affecting post-translational modification (PTM) sites in human genes/proteins using online ActiveDriverDB database. Needle plots indicate the PTM site mutations in our genes/proteins. The graph shows the outcomes based on the specific type of PTM, cancer type, and mutation subset (presented in legend color codes). Height (y-axis) represents the number of occurrences of the mutation while Horizontal position (x-axis) indicates the position of protein’s amino acid sequence. Pinhead color signifies the mutation impact and X-axis coloring shows the type of PTM associated with the mutation location. Mutational Impacts: Rewiring: mutation-induced gains and losses of kinase-bound sequence motifs (predicted by MIMP software); Distal: mutation affects an amino acid located 4–7 amino acids away from the PTM site; Direct: mutation affects the post transcriptionally modified amino acid; Proximal: mutation affects an amino acid located 1–3 amino acids away from PTM site; Sites: Amino acid sites/ regions enriched for mutations affecting post-translational modifications (PTMs).