Table 3 Gene Ontology and functional enrichment of differentially expressed genes.
From: Systems-level differential gene expression analysis reveals new genetic variants of oral cancer
Term | p value | Fold enrichment | FDR |
---|---|---|---|
hsa04913: Ovarian steroidogenesis | 4.86E−04 | 70.5102 | 0.464991 |
GO:0,097,267 ~ omega-hydroxylase P450 pathway | 2.68E−03 | 621.9259 | 2.926305 |
GO:0,016,712 ~ oxidoreductase activity | 0.00355 | 450.16 | 2.812419 |
GO:0,019,373 ~ epoxygenase P450 pathway | 0.005349 | 310.963 | 5.768479 |
GO:0,070,330 ~ aromatase activity | 0.006383 | 250.0889 | 5.007033 |
GO:0,019,825 ~ oxygen binding | 0.011091 | 143.6681 | 8.558457 |
GO:0,008,202 ~ steroid metabolic process | 0.01274 | 130.1705 | 13.24158 |
IPR002401: Cytochrome P450, E-class, group I | 0.0134 | 123.7267 | 9.757773 |
GO:0,004,497 ~ monooxygenase activity | 0.013674 | 116.4207 | 10.45655 |
IPR017972: Cytochrome P450, conserved site | 0.01553 | 106.6609 | 11.23041 |
IPR001128: Cytochrome P450 | 0.017126 | 96.66146 | 12.31951 |
GO:0,071,407 ~ cellular response to organic cyclic compound | 0.017447 | 94.87006 | 17.71563 |
Monooxygenase | 0.021199 | 77.95833 | 17.98805 |
GO:0,031,090 ~ organelle membrane | 0.023645 | 69.82375 | 15.90821 |
Metal ion-binding site: Iron (heme axial ligand) | 0.024432 | 67.55219 | 18.69242 |
hsa00380: Tryptophan metabolism | 0.028619 | 57.58333 | 24.30038 |
Microsome | 0.030952 | 53.18088 | 25.24757 |
Heme | 0.031663 | 51.97222 | 25.75335 |
GO:0,020,037 ~ heme binding | 0.032072 | 49.28759 | 23.01009 |
Secondary metabolites biosynthesis, transport, and catabolism | 0.032577 | 30.69697 | 3.257651 |
GO:0,005,506 ~ iron ion binding | 0.035767 | 44.13333 | 25.3362 |
hsa00140: Steroid hormone biosynthesis | 0.041281 | 39.71264 | 33.24928 |
hsa00980: Metabolism of xenobiotics by cytochrome P450 | 0.052426 | 31.12613 | 40.32831 |
hsa05204: Chemical carcinogenesis | 0.056578 | 28.79167 | 42.78879 |
hsa04914: Progesterone-mediated oocyte maturation | 0.061404 | 26.4751 | 45.53397 |
Glycoprotein | 0.075408 | 3.014869 | 51.59749 |
Iron | 0.076281 | 21.17387 | 52.01866 |
hsa04114: Oocyte meiosis | 0.076443 | 21.1315 | 53.34849 |
hsa04114: Oocyte meiosis | 0.076443 | 21.1315 | 53.34849 |