Table 3 Gene Ontology and functional enrichment of differentially expressed genes.

From: Systems-level differential gene expression analysis reveals new genetic variants of oral cancer

Term

p value

Fold enrichment

FDR

hsa04913: Ovarian steroidogenesis

4.86E−04

70.5102

0.464991

GO:0,097,267 ~ omega-hydroxylase P450 pathway

2.68E−03

621.9259

2.926305

GO:0,016,712 ~ oxidoreductase activity

0.00355

450.16

2.812419

GO:0,019,373 ~ epoxygenase P450 pathway

0.005349

310.963

5.768479

GO:0,070,330 ~ aromatase activity

0.006383

250.0889

5.007033

GO:0,019,825 ~ oxygen binding

0.011091

143.6681

8.558457

GO:0,008,202 ~ steroid metabolic process

0.01274

130.1705

13.24158

IPR002401: Cytochrome P450, E-class, group I

0.0134

123.7267

9.757773

GO:0,004,497 ~ monooxygenase activity

0.013674

116.4207

10.45655

IPR017972: Cytochrome P450, conserved site

0.01553

106.6609

11.23041

IPR001128: Cytochrome P450

0.017126

96.66146

12.31951

GO:0,071,407 ~ cellular response to organic cyclic compound

0.017447

94.87006

17.71563

Monooxygenase

0.021199

77.95833

17.98805

GO:0,031,090 ~ organelle membrane

0.023645

69.82375

15.90821

Metal ion-binding site: Iron (heme axial ligand)

0.024432

67.55219

18.69242

hsa00380: Tryptophan metabolism

0.028619

57.58333

24.30038

Microsome

0.030952

53.18088

25.24757

Heme

0.031663

51.97222

25.75335

GO:0,020,037 ~ heme binding

0.032072

49.28759

23.01009

Secondary metabolites biosynthesis, transport, and catabolism

0.032577

30.69697

3.257651

GO:0,005,506 ~ iron ion binding

0.035767

44.13333

25.3362

hsa00140: Steroid hormone biosynthesis

0.041281

39.71264

33.24928

hsa00980: Metabolism of xenobiotics by cytochrome P450

0.052426

31.12613

40.32831

hsa05204: Chemical carcinogenesis

0.056578

28.79167

42.78879

hsa04914: Progesterone-mediated oocyte maturation

0.061404

26.4751

45.53397

Glycoprotein

0.075408

3.014869

51.59749

Iron

0.076281

21.17387

52.01866

hsa04114: Oocyte meiosis

0.076443

21.1315

53.34849

hsa04114: Oocyte meiosis

0.076443

21.1315

53.34849