Table 5 Over-representation of oral cancer-related DEGs using oPOSSUM with 80% matrix score.
From: Systems-level differential gene expression analysis reveals new genetic variants of oral cancer
TF | Class | Family | Tax group | IC | Target gene hits | Target gene non-hits | Back-ground gene hits | Back-ground gene non-hits | Target TFBS hits | Target TFBS nucleotide rate | Back-ground TFBS hits | Back-ground TFBS nucleotide rate | Z-score | Fisher score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ESR1 | Zinc-coordinating | Hormone-nuclear Receptor | Vertebrates | 13.563 | 1 | 5 | 345 | 24,407 | 1 | 0.00319 | 355 | 0.000197 | 16.419 | 2.514 |
Arnt::Ahr | Zipper-Type | Helix-Loop-Helix | Vertebrates | 9.532 | 5 | 1 | 13,597 | 11,155 | 23 | 0.022 | 66,086 | 0.011 | 8.273 | 1.815 |
CEBPA | Zipper-Type | Leucine Zipper | Vertebrates | 8.712 | 5 | 1 | 12,828 | 11,924 | 18 | 0.0258 | 55,606 | 0.0139 | 8.01 | 2.06 |
CTCF | Zinc-coordinating | Beta Alpha-zinc finger | Vertebrates | 17.205 | 2 | 4 | 3,236 | 21,516 | 2 | 0.00606 | 3,982 | 0.0021 | 6.703 | 1.718 |
HNF1B | Helix-Turn-Helix | Homeo | Vertebrates | 16.821 | 3 | 3 | 4,107 | 20,645 | 3 | 0.00574 | 6,910 | 0.0023 | 5.543 | 2.787 |
ELK4 | Winged Helix-Turn-Helix | Ets | Vertebrates | 14.123 | 2 | 4 | 6,034 | 18,718 | 4 | 0.00574 | 9,342 | 0.00234 | 5.452 | 0.796 |
TAL1::TCF3 | Zipper-Type | Helix-Loop-Helix | Vertebrates | 14.07 | 2 | 4 | 7,491 | 17,261 | 5 | 0.00957 | 14,681 | 0.0049 | 5.21 | 0.535 |
Nr2e3 | Zinc-coordinating | Hormone-nuclear Receptor | Vertebrates | 12.028 | 4 | 2 | 6,354 | 18,398 | 5 | 0.00558 | 12,287 | 0.00239 | 5.045 | 3.187 |
Lhx3 | Helix-Turn-Helix | Homeo | Vertebrates | 16.354 | 2 | 4 | 5,806 | 18,946 | 4 | 0.00829 | 12,758 | 0.00461 | 4.212 | 0.846 |
Nkx2-5 | Helix-Turn-Helix | Homeo | Vertebrates | 8.27 | 6 | 0 | 16,973 | 7,779 | 43 | 0.048 | 197,210 | 0.0384 | 3.939 | 2.263 |
Arnt | Zipper-Type | Helix-Loop-Helix | Vertebrates | 10.992 | 4 | 2 | 7,052 | 17,700 | 5 | 0.00478 | 13,904 | 0.00232 | 3.928 | 2.827 |
NFE2L2 | Zipper-Type | Leucine Zipper | Vertebrates | 14.394 | 2 | 4 | 5,635 | 19,117 | 3 | 0.00526 | 8,970 | 0.00274 | 3.696 | 0.886 |
ESR2 | Zinc-coordinating | Hormone-nuclear Receptor | Vertebrates | 13.618 | 1 | 5 | 2,219 | 22,533 | 1 | 0.00287 | 2,670 | 0.00134 | 3.155 | 0.842 |
Tal1::Gata1 | Zipper-Type | Helix-Loop-Helix | Vertebrates | 11.297 | 2 | 4 | 6,212 | 18,540 | 3 | 0.00861 | 11,200 | 0.0056 | 3.107 | 0.758 |
Evi1 | Zinc-coordinating | BetaBetaAlpha-zinc finger | Vertebrates | 17.909 | 1 | 5 | 1931 | 22,821 | 1 | 0.00223 | 2,457 | 0.000956 | 3.067 | 0.952 |
PLAG1 | Zinc-coordinating | BetaBetaAlpha-zinc finger | Vertebrates | 19.352 | 1 | 5 | 1971 | 22,781 | 1 | 0.00223 | 2,462 | 0.000958 | 3.059 | 0.936 |
MZF1_5-13 | Zinc-coordinating | BetaBetaAlpha-zinc finger | Vertebrates | 9.4 | 5 | 1 | 13,425 | 11,327 | 17 | 0.0271 | 77,649 | 0.0216 | 2.97 | 1.868 |
STAT1 | Ig-fold | Stat | Vertebrates | 13.119 | 2 | 4 | 6,394 | 18,358 | 3 | 0.00717 | 10,990 | 0.00458 | 2.949 | 0.722 |
Mycn | Zipper-Type | Helix-Loop-Helix | Vertebrates | 11.104 | 3 | 3 | 8,332 | 16,420 | 5 | 0.00797 | 18,928 | 0.00526 | 2.883 | 1.12 |
Prrx2 | Helix-Turn-Helix | Homeo | Vertebrates | 9.063 | 4 | 2 | 15,063 | 9,689 | 27 | 0.0215 | 123,270 | 0.0171 | 2.636 | 0.576 |
FOXD1 | Winged Helix-Turn-Helix | Forkhead | Vertebrates | 11.926 | 6 | 0 | 13,087 | 11,665 | 14 | 0.0179 | 62,921 | 0.014 | 2.556 | 3.823 |
MEF2A | Other Alpha-Helix | MADS | Vertebrates | 15.709 | 2 | 4 | 7,006 | 17,746 | 4 | 0.00638 | 15,631 | 0.00434 | 2.354 | 0.612 |
Gfi | Zinc-coordinating | BetaBetaAlpha-zinc finger | Vertebrates | 9.47 | 4 | 2 | 13,731 | 11,021 | 14 | 0.0223 | 65,844 | 0.0183 | 2.332 | 0.796 |
FOXO3 | Winged Helix-Turn-Helix | Forkhead | Vertebrates | 11.734 | 5 | 1 | 13,611 | 11,141 | 15 | 0.0191 | 69,410 | 0.0154 | 2.328 | 1.811 |
