Table 7 Databases and tools used during this meta-analysis.

STRING database version 11

https://string-db.org/

For known and predicted protein/COGs interaction

74

National Center for Biotechnology Information (NCBI)

https://ncbi.nlm.nih.gov

Biomedical and genomic information source

–

Cytoscape version 3.6.0

https://www.cytoscape.org/

For network analysis and visualization

31

DAVID Bioinformatics tool 6.8

https://david.abcc.ncifcrf.gov

Gene ontology/

Functional Annotation tool

75

Uniprot

https://www.uniprot.org/

Resource of protein functional information

76

Kyoto Encyclopedia of Genes and Genomes (KEGG)

https://www.genome.jp/

Pathways analysis and comparison

77

FunRich version 3

www.funrich.org/

Enrichment analysis

24

R version 3.3.3

https://www.r-project.org/

Statistical computing/data mining

14–16

Opossum Version 3.0

https://opossum.cisreg.ca/oPOSSUM3/

Single site analysis

78

Wiki-Pathways

https://www.wikipathways.org/index.php/WikiPathways

Pathways analysis

79

Path-Visio 3.3.0

https://www.pathvisio.org/

pathway analysis and drawing software

34

Comparative Toxicogenomics Database CTD

https://ctdbase.org/

gene–disease relationships

80

CIMminer

https://discover.nci.nih.gov/cimminer/home.do

Cluster analysis

25–26

HAPPI version 2,0

https://discovery.informatics.uab.edu/HAPPI/

Protein–protein interaction

30