Table 2 KEGG signalling pathways related to skin appendage differentiation with DEGs between embryo-scale and adult-scale (embryo-scale vs adult-scale group).
KEGG ID | KEGG pathway | padj | Up-regulated gene in embryo-scale group | Up-regulated gene in adult-scale group |
|---|---|---|---|---|
mmu04151 | PI3K-Akt signaling pathway |  < 0.001 | FGFR4, LPAR6, CREB3L1, PDGFB, LAMA5, LAMB2, NTF3, FGF22, FGFR1, CCND1, FGF17, NGF, ITGB6, FGFR2, CDK2 | MCL1, OSMR, GNG3, CSF3R, CSF3, FGF1, KRAS, CHUK, AKT3, SGK1, THBS4, ANGPT2, NFKB1, TLR4, SGK3 |
mmu04512 | ECM-receptor interaction |  < 0.001 | FRAS1, THBS3, HMMR, ITGB7, AGRN, NPNT, LAMA5, LAMB2, SV2A, ITGB6, ITGA11, CHAD, ITGA5 | SDC4, THBS4 |
mmu04340 | Hedgehog signaling pathway | 0.013 | PTCH2, BOC, GLI2, SMO, KIF7, GLI1, CCND1, GLI3, MEGF8, HHIP | SPOPL, PRKACB |
mmu04510 | Focal adhesion | 0.042 | MYL7, THBS3, ITGB7, MYL10, VAV2, PDGFB, LAMA5, LAMB2, CCND1, ITGB6, ITGA11, MYL9 | BIRC3, IGF1R, AKT3, THBS4 |
mmu04068 | FoxO signaling pathway | 0.074 | CCNB1, PLK1, CCND1, CDK2 | SOD2, FBXO32, STAT3, FOXO1, IGF1R, KRAS, CHUK, S1PR1, AKT3, SGK1, S1PR4, SGK3 |
mmu04668 | TNF signaling pathway | 0.126 | CREB3L1, FIGF, RIPK3, PIK3R2, JAG1 | CEBPB, SOCS3, IL6, CCL20, BIRC3, MMP9, TNFAIP3, CHUK, TNFRSF1B, AKT3, MAP3K8, NFKB1 |
mmu04514 | Cell adhesion molecules (CAMs) | 0.380 | NLGN2, ITGB7, CLDN7, CNTNAP1, VCAN, CLDN8, CNTN2, CD34, LRRC4B, L1CAM | SELP, CD2, LOC108391351, PTPRC, SELL, ITGAM, SDC4, PECAM1, CDH2 |
mmu04115 | p53 signaling pathway | 0.380 | CHEK2, CCNB1, CCND1, TSC2, CDK2 | PMAIP1, RPRM, SERPINE1, GADD45A, SESN1, AIFM2, IGFBP3 |
mmu04330 | Notch signaling pathway | 0.380 | DTX4, JAG2, KAT2A, DLL1, NOTCH1, NOTCH3, DTX1, JAG1 | KAT2B, ATXN1L |
mmu04630 | JAK-STAT signaling pathway | 0.420 | PDGFB, CCND1 | MCL1, STAT3, SOCS3, OSMR, CSF3R, CSF3, CSF2RB, AOX1, AKT3 |
mmu03320 | PPAR signaling pathway | 0.460 | RXRG, PLIN5, HMGCS2, ILK | ACSL4, MMP1, SORBS1, PLTP, PLIN2 |
mmu04210 | Apoptosis | 0.760 | SEPT4, NGF, SPTAN1, LMNB2 | PMAIP1, MCL1, BIRC3, CTSS, KRAS, CHUK, AKT3, NFKB1 |
mmu04010 | MAPK signaling pathway | 0.773 | FGFR4, MAP3K6, PDGFB, NTF3, MAP4K2, FGF22, IGF2, FGFR1, FGF17, NGF, FGFR2 | CD14, SRF, PRKACB, FGF1, KRAS, CHUK, AKT3, ELK4, DUSP3, ANGPT2, NFKB1 |
mmu04310 | Wnt signaling pathway | 0.936 | SFRP2, TCF7, ROR2, LEF1, PRICKLE2, SFRP4, WNT8B, NOTUM, AXIN2, RSPO3, LGR5, CCND1, WNT10B, WNT4 | FOSL1, PRKACB |
mmu04530 | Tight junction | 1.000 | CLDN7, TJP3, CLDN8, CCND1, MYH7B, MICALL2, ARHGEF2, MYL9 | PRKACB, ACTR2, YBX3, PRKAB2, SYNPO |
mmu04110 | Cell cycle | 1.000 | CHEK2, ESPL1, CCNB1, PLK1, CDC45, CCND1, PTTG1, CDK2 | GADD45A |
mmu04350 | TGF-beta signaling pathway | 1.000 | FMOD, RGMB, AMH, FBN3, ID3, TGIF2 | INHBB |
mmu04012 | ErbB signaling pathway | 1.000 | PLCG1, PIK3R2 | KRAS, AKT3 |
mmu04390 | Hippo signaling pathway | 1.000 | TCF7, GLI2, LEF1, AMH, WNT8B, AXIN2, CCND1, WNT10B, WNT4, CRB2, | SERPINE1, FGF1, TEAD4 |
