Table 3 Top genetic polymorphisms associated with log-transformed FGF23 level.

From: Genome-wide association study for circulating fibroblast growth factor 21 and 23

SNP

Chr

Position

Nearest gene

FGF23 Increasing allele

Other allele

FGF23 increasing allele frequency

Model 1

Model 2

Model 3

P value

Beta (SEM)

P value

Beta (SEM)

P value

Beta (SEM)

rs17111495

1

55,500,706

PCSK9

G

C

0.98

1.04 × 10–10

0.463 (0.071)

1.57 × 10–10

0.458 (0.071)

1.55 × 10–10

0.458 (0.071)

rs17843626

6

32,621,013

HLA-DQA1

G

A

0.49

1.80 × 10–8

0.117 (0.021)

1.70 × 10–8

0.117 (0.021)

1.75 × 10–8

0.117 (0.021)

rs2798631

1

218,611,878

TGFB2

G

A

0.75

4.97 × 10–7

0.115 (0.023)

3.73 × 10–7

0.116 (0.023)

3.71 × 10–7

0.116 (0.023)

  1. Model 1 was adjusted for age, sex and the first ten principal components of ancestry. Model 2 was additionally adjusted for BMI. Model 3 was additionally adjusted for BMI and eGFR. SNP single nucleotide polymorphism; Chr chromosome. rs17111495, rs2798631 and rs17843626 are imputed with high info scores (0.809, 0.997 and 0.990 respectively).
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