Table 2 Correlations between ENE in SLN and non-SLN metastasis.
From: Clinical significance of extranodal extension in sentinel lymph node positive breast cancer
Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
OR | 95% CI | P value | OR | 95% CI | P value | |
Age (Y) | ||||||
< 50 | 1 | – | – | |||
≥ 50 | 0.8 | 0.49–1.30 | 0.359 | |||
Pathological T stage | ||||||
T1 | 1 | – | – | |||
T2 | 1.13 | 0.70–1.83 | 0.62 | |||
Histological grade | ||||||
2 | 1 | – | – | |||
3 | 0.88 | 0.54–1.43 | 0.602 | |||
No. of SLN metastasis | ||||||
≤ 2 | 1 | – | – | 1 | – | – |
> 2 | 2.84 | 1.50–5.37 | 0.001 | 1.59 | 0.73–3.44 | 0.243 |
Pattern of SLN metastasis | ||||||
Micrometastasis | 1 | – | – | 1 | – | – |
Macrometastasis | 5.09 | 2.03–12.75 | 0.001 | 2.1 | 0.69–6.39 | 0.193 |
ENE | ||||||
Negative | 1 | – | – | 1 | – | – |
Positive | 7.77 | 4.39–13.76 | < 0.001 | 4.8 | 2.47–9.34 | < 0.001 |
ER status | ||||||
Negative | 1 | – | – | |||
Positive | 2.43 | 1.27–4.63 | 0.007 | 1.11 | 0.37–3.35 | 0.856 |
PR status | ||||||
Negative | 1 | – | – | 1 | – | – |
Positive | 2.93 | 1.64–5.23 | < 0.001 | 1.6 | 0.61–4.21 | 0.338 |
HER2 status | ||||||
Negative | 1 | – | – | |||
Positive | 0.38 | 0.20–0.74 | 0.004 | 0.31 | 0.12–0.75 | 0.010 |
Molecular subtype | ||||||
Luminal A-like | 1 | – | – | |||
Luminal B-like | 0.78 | 0.54–1.60 | 0.78 | |||
HER2 overexpreesion | 0.26 | 0.09–1.37 | 0.053 | |||
TNBC | 0.41 | 0.15–1.12 | 0.082 | |||
Lympho-vascular invasion | ||||||
No | 1 | – | – | 1 | – | – |
Yes | 7.23 | 4.21–12.43 | < 0.001 | 6.02 | 3.24–11.18 | < 0.001 |
