Figure 5 | Scientific Reports

Figure 5

From: Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK–Akt–eNOS pathway in the isoprenaline-induced oxidative stress model

Figure 5

Canagliflozin (Canaglif) reduces ISO-mediated upregulation of NOX4 and iNOS. (A) Representative Western blot image showing a reduction of Nox4 protein expression by canagliflozin. Full-length Western blot images are presented in supplementary figure 3. (B) Mean data for changes of Nox4 expression normalized to α-actin. n = 4 for each group. (C) Representative Western blot image showing a reduction of ISO-mediated iNOS upregulation by canagliflozin treatment. (D) Mean data for changes of iNOS expression normalized to α-actin or GAPDH expression. One-way ANOVA with Newman–Keuls post hoc test was used for multiple group comparisons. Data are presented as mean ± SEM. n = 4 for each group. * indicates p < 0.05 vs control, # indicates p < 0.05 vs ISO.

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