Table 1 Correlation of clinical/laboratory parameters with the number of NI type1/type2.

From: Characterization of two types of intranuclear hepatocellular inclusions in NAFLD

Parameters

n valid cases

Number of NI type1

Number of NI type2

Median valueb

P value*

Median valueb

P value*

Fasting glucose (mg/dl)

Normal (70–99)

19

0.42 (0–1.98)

0.032

0.35 (0–27.23)

0.068

Pre-diabetes and diabetesa

35

1.12 (0–8.46)

 

4.03 (0–78.49)

 

Total cholesterol (mg/dl)

Normal (< 200)

20

0.87 (0–8.46)

0.598

4.1 (0–61.39)

0.730

Elevated (> 200)

13

1.12 (0.26–3.79)

 

5.9 (0–78.49)

 

Triglyceride (mg/dl)

Normal (< 200)

18

0.66 (0–2.32)

0.006

0.8 (0–31.04)

0.001

Elevated (> 200)

7

2.33 (0.7–8.46)

 

27.2 (10.4–78)

 

ALT (U/L)

Normal (< 35/ < 50)

40

0.59 (0–8.46)

0.078

0.73 (0–61.4)

0.444

Elevated (> 35/ > 50)

24

1.05 (0–6.18)

 

2.73 (0–78.5)

 

AST (U/L)

Normal (< 35/ < 50)

28

0.59 (0–8.46)

0.617

0.33 (0–61.4)

0.204

Elevated (> 35/ > 50)

16

1.05 (0–6.18)

 

6.09 (0–78.5)

 

GGT (U/L)

Normal (< 35/ < 55)

42

0.61 (0–6.18)

0.134

0.37 (0–61.4)

0.050

Elevated (> 35/ > 55)

22

0.92 (0–8.46)

 

4.2 (0–78.5)

 

Fibrosis grade

0

10

1.15 (0–2.19)

 

0.55 (0–38.2)

 

1

16

0.61 (0–2.32)

 

0.95 (0–31)

 

2

28

0.96 (0–10)

0.179

4.8 (0–78.5)

0.159

3

4

0.48 (0–1.3)

 

2.04 (0–8.67)

 

Steatosis grade

0

19

0.06 (0–0.21)

 

0.17 (0–14.96)

 

1

28

0.6 (0–2.19)

 

0.4 (0–38.25)

 

2

18

1.17 (0–8.43)

 < 0.001

2.25 (0–61.39)

 < 0.001

3

12

1.99 (0.61–10)

 

12.8 (0.1–78.5)

 

Ballooning grade

0

37

0.11 (0–1.86)

 

0.17 (0–27.23)

 

1

21

1.15 (0–3.53)

 < 0.001

1.88 (0–61.39)

 < 0.001

2

19

1.67 (0.21–10)

 

8.67 (0.1–78.5)

 

Lobular inflammation grade

0

35

0.11 (0–2.19)

 

0.21 (0–38.25)

 

1

16

1.05 (0–8.46)

 

1.51 (0–37.24)

 

2

24

1.47 (0–10)

 < 0.001

4.06 (0–78.49)

0.004

3

2

0.44 (0.28–0.6)

 

1.8 (0.76–2.84)

 
  1. aWe defined fasting blood glucose level of 100–125 mg/dl as pre-diabetes and glucose levels of ≥ 126 mg/dl as diabetes.
  2. bValues are median number of type1/2 NI per 1,000 cells with ranges presented in parentheses. ALT and AST threshold for normal values were < 35 U/l for females and < 50 U/l for males; GGT threshold for normal values were < 35 U/l for females and < 55 U/l for males.
  3. *P values correspond to the analysis of correlation between clinical/laboratory parameters with the number of type1/type2 NI in the HCC cohort. Mann–Whitney U-test and Kruskal–Wallis-tests were used for statistical analysis of the difference between two or more groups. Results are significant at P ≤ 0.05.
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