Figure 1

Radiographic and cone-beam computed tomography (CBCT) images of a 9 year-old girl with a homozygous SMOC2 mutation (also see Ref.¹²). (A,B) Respective frontal and lateral radiographic views of the skull. Cranial bones and sutures, sella turcica, and orbit structures are normal except for the maxilla and mandible. (C) A full-frontal view of the dentition. The lower dentition displays more severe oligodontia and microdontia compared with the upper teeth. Affected teeth are typically 15–20% smaller than normal, except for the lower right first molar (red arrowhead), which is bigger. (D) Extracted CBCT images of full-lateral views. Defects include macrodontia (red arrowhead) and microdontia (yellow arrowhead). (E,F) Extracted frontal and lateral views with the lower dentition displaying more severe oligodontia and microdontia compared with the upper teeth. Image extraction of isolated teeth (using the Analyze 11.0 software) shows that a micro-root structure consistently accompanies microdontia. A false blue background was added using the Analyze 11.0 software (C–F), and the figure was labelled with Adobe Photoshop CS6.