Figure 3
From: Genetic variation regulates opioid-induced respiratory depression in mice
Strain- and sex-specific effect of morphine on respiratory sensitivity. Respiratory depression (top left panel), recovery time (middle left panel) and survival time (bottom left panel) were determined using the probe dose of 436 mg/kg and the PiezoSleep system. The traits of recovery time or survival time are censored such that a mouse does not appear in both graphs as each mouse displays only one of these two phenotypes. Empty bars indicate that no mice fell into this category (i.e., either all recovered, or none recovered). Scatterplot of percent respiratory depression vs recovery time (top right panel) showing a weak correlation of R2 of 0.08; and a scatterplot of percent respiratory depression vs survival time (bottom right panel) showing no significant correlation. Microsoft 365 https://www.microsoft.com/en-us/microsoft-365?rtc=1 and JMP 15.0.0 https://www.jmp.com.
