Table 2 Enrichment analysis of significantly enriched PFAM domains, KEGG metabolic pathways, and molecular function GO terms among differentially expressed proteins (DEPs). Significant GO terms are reported here.

From: Greenbug (Schizaphis graminum) herbivory significantly impacts protein and phosphorylation abundance in switchgrass (Panicum virgatum)

GO terms significantly enriched

# of GO terms present in reference genome

# of GO term hits among DEPs

p value

Adjusted p value

Enrichment analysis of upregulated DEPs

Catalytic activity

14,617

146

3.63E−35

1.19E−32

Molecular function

27,777

190

1.35E−26

4.44E−24

Biological process

19,951

147

3.98E−21

2.22E−18

Metabolic process

15,661

125

5.41E−20

3.02E−17

Hydrolase activity

4,253

59

5.30E−19

1.74E−16

Oxidoreductase activity

3,021

46

2.33E−16

7.67E−14

Oxidation–reduction process

2,547

42

3.60E−16

2.01E−13

Hydrolase activity, hydrolyzing O-glycosyl compounds

730

22

5.84E−14

1.92E−11

Hydrolase activity, acting on glycosyl bonds

814

23

5.88E−14

1.93E−11

Cofactor binding

1,827

29

4.53E−11

1.49E−08

Carbohydrate metabolic process

1,098

20

5.45E−09

3.05E−06

Response to oxidative stress

336

11

5.43E−08

3.04E−05

Heme binding

961

17

1.18E−07

3.88E−05

Tetrapyrrole binding

964

17

1.23E−07

4.05E−05

Antioxidant activity

365

11

1.25E−07

4.11E−05

Response to stress

1,055

18

8.49E−08

4.75E−05

Binding

16,455

97

2.12E−07

6.97E−05

Chitinase activity

37

5

2.40E−07

7.90E−05

Metal ion binding

3,558

34

3.20E−07

0.000105

Cation binding

3,586

34

3.82E−07

0.000126

Glucosamine-containing compound catabolic process

37

5

2.40E−07

0.000134

Glucosamine-containing compound metabolic process

37

5

2.40E−07

0.000134

Amino sugar metabolic process

37

5

2.40E−07

0.000134

Aminoglycan catabolic process

37

5

2.40E−07

0.000134

Chitin catabolic process

37

5

2.40E−07

0.000134

Chitin metabolic process

37

5

2.40E−07

0.000134

Amino sugar catabolic process

37

5

2.40E−07

0.000134

Peroxidase activity

339

10

5.69E−07

0.000187

Oxidoreductase activity, acting on peroxide as acceptor

343

10

6.33E−07

0.000208

Drug catabolic process

41

5

4.07E−07

0.000228

Cell wall macromolecule catabolic process

41

5

4.07E−07

0.000228

Cell wall macromolecule metabolic process

46

5

7.34E−07

0.000410

Aminoglycan metabolic process

46

5

7.34E−07

0.000410

Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

52

5

1.37E−06

0.000451

Dioxygenase activity

55

5

1.81E−06

0.000595

Carbohydrate derivative catabolic process

55

5

1.81E−06

0.001012

Response to stimulus

1,790

21

3.13E−06

0.001750

Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

70

5

6.04E−06

0.001987

Peptidase activity

1,134

15

2.12E−05

0.006975

Exopeptidase activity

152

6

2.14E−05

0.007041

Proteolysis

1,223

16

1.29E−05

0.007211

Magnesium ion binding

238

7

2.94E−05

0.009673

Lyase activity

431

9

3.28E−05

0.010791

Hydrolase activity, acting on acid phosphorus-nitrogen bonds

348

8

4.60E−05

0.015134

Serine-type peptidase activity

348

8

4.60E−05

0.015134

Serine hydrolase activity

348

8

4.60E−05

0.015134

Serine-type carboxypeptidase activity

111

5

5.66E−05

0.018621

Carboxypeptidase activity

113

5

6.16E−05

0.020266

Peptidase activity, acting on L-amino acid peptides

1,105

14

6.30E−05

0.020727

Terpene synthase activity

114

5

6.43E−05

0.021155

Cell wall organization or biogenesis

172

6

4.29E−05

0.023981

Serine-type exopeptidase activity

120

5

8.20E−05

0.026978

Carbon–oxygen lyase activity, acting on phosphates

121

5

8.53E−05

0.028064

Ion binding

8,249

51

0.00011

0.036848

Enrichment analysis of downregulated DEPs

Photosynthesis, light harvesting

32

7

1.23E−13

6.88E−11

Catalytic activity

14,617

61

1.75E−12

5.76E−10

Photosynthesis, light reaction

56

7

8.22E−12

4.59E−09

Biological process

19,951

71

1.75E−11

9.78E−09

Photosynthesis

154

8

3.28E−10

1.83E−07

Generation of precursor metabolites and energy

233

9

3.47E−10

1.94E−07

Metabolic process

15,661

57

3.45E−09

1.93E−06

Carbohydrate metabolic process

1,098

12

5.08E−07

0.000284

Molecular function

27,777

75

1.57E−06

0.000517

Protein folding

193

6

1.18E−06

0.000660

Oxidoreductase activity

3,021

18

4.77E−06

0.001569

Hydrolase activity, hydrolyzing O-glycosyl compounds

730

8

4.23E−05

0.013917

Protein import

36

3

3.40E−05

0.019006

Oxidation–reduction process

2,547

15

3.56E−05

0.019900

Hydrolase activity, acting on glycosyl bonds

814

8

9.01E−05

0.029643