Table 3 Correlation coefficients for associations between striatal shape, limits of stability and RTD in individuals with pro-HD and HC (Pearson’s) and associations between relative RTD and measures of disease burden (Spearman’s).

From: Rate of torque development and striatal shape in individuals with prodromal Huntington's disease

 

Relative rate of torque development

Pro-HD

HC

Left caudate

0.71 (0.000)

 − 0.07 (0.784)

Right caudate

0.60 (0.004)

 − 0.29 (0.238)

Left putamen

0.66 (0.001)

 − 0.11 (0.654)

Right putamen

0.65 (0.002)

 − 0.28 (0.244)

Reaction time (ms)

 − 0.00 (0.996)

 − 0.14 (0.553)

Movement velocity (deg/s)

0.01 (0.946)

0.34 (0.161)

End point

Excursion (%)

0.49 (0.032)

 − 0.05 (0.820)

Maximum excursion (%)

0.40 (0.087)

 − 0.05 (0.843)

Directional control (%)

0.43 (0.060)

0.01 (0.950)

Disease burden score

 − 0.42 (0.053)

CAP score

 − 0.37 (0.094)

UHDRS-TMS

 − 0.69 (0.000)

  1. pro-HD prodromal Huntington’s disease, HC healthy controls, RTD rate of torque development, UHDRS-TMS Unified Huntington’s Disease Rating Scale-Total Motor Score, CAP score CAG-Age Product Scaled score, RTD rate of torque development. Data are presented as correlation coefficients (p value). Results were considered significant at p < 0.05.