Figure 4 | Scientific Reports

Figure 4

From: Males and females exhibit distinct relationships between intervertebral disc degeneration and pain in a rat model

Figure 4

Mechanical allodynia exhibited a pronounced sex effect. Mechanical allodynia was measured using manual application of von Frey filaments. (a) Male rats showed a large reduction in paw withdrawal threshold (increase in mechanical allodynia) after injury, which persisted over time. (b) Female rats had highly variable paw withdrawal threshold values, and no difference was seen between injury and sham control. (c,d) Post-operative variability could not be explained baseline variability, as normalizing to baseline did not affect variability of later measurements. (n = 11–12, ****p < 0.0001).

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