Figure 3

Mutational signature analysis of SDC. (A) Mutational signature analysis of SDC cohort. Point mutations of SDC samples were aggregated to form a set of ‘ensemble SDC mutations’. This ensemble mutation set was used in mutation signature analysis to decipher representative signatures in SDC cohort. (B) Contribution of mutation signatures to each SDC sample. Somatic mutations identified from genomic sequencing of SDC samples were subjected to mutation signature analysis per sample. Patterns of 1937 single-nucleotide mutations in 10 SDC samples were analyzed and the contribution of each signature to the mutagenesis of SDC samples are shown. X-axis is the name of sample and y-axis is the relative contribution of mutation signature normalized per sample. (C) Comparison of mutation rate between samples with and without APOBEC/AID signatures. The number of somatic mutations in the exonic region of SDC between groups with and without APOBEC/AID signatures (signature 2,13/9) were compared and presented in the box-plot.