Figure 4 | Scientific Reports

Figure 4

From: Structure-based inhibitors targeting the alpha-helical domain of the Spiroplasma melliferum histone-like HU protein

Figure 4

Monitoring of chemical shift perturbations (CSPs) and cross-peak intensity perturbations (CIPs) of backbone amide groups of the HUSpm dimer in its free form (A,B,E,F) and in complex with DS14 (C,D,G,H) upon BDF4 binding. Weighted CSPs (A,C,E,G) and normalized CIPs (B,D,F,H) of the HUSpm residues after binding BDF4 shown as diagrams (A–D) and their color-coded mapping on ribbon models of the HUSpm dimer (E–H). Green, yellow and red lines in (A–D) are cutoff levels for the color-coding used in (E–H).

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