Table 1 Clinicopathologic characteristics of patients with clinical N2 disease before and after inverse probability of treatment weighting (N = 268).

From: Video-assisted thoracoscopic lobectomy is feasible for selected patients with clinical N2 non-small cell lung cancer

Variables

Overall cohort

IPTW-adjusted cohort

VATS (n = 121)

Thoracotomy (n = 147)

p value

VATS (n = 121)

Thoracotomy (n = 147)

p value

SMD

Operation period

2007–2010

33 (27.3)

59 (40.1)

0.038

37 (30.6)

50 (34.0)

0.616

0.073

2011–2013

27 (22.3)

31 (21.1)

0.926

29 (24.0)

32 (21.8)

0.794

0.039

2014–2016

61 (50.4)

57 (38.8)

0.074

55 (45.4)

65 (44.2)

0.809

0.035

Age, year

64.0 ± 10.4

62.4 ± 9.5

0.189

63.8 ± 10.2

63.4 ± 9.5

0.742

0.046

Sex, male

76 (62.8)

120 (81.6)

0.001

87 (71.9)

111 (75.5)

0.582

0.081

History of smoking

76 (62.8)

119 (81.0)

0.001

88 (72.7)

111 (75.5)

0.687

0.058

Comorbidities per patient, n

0

46 (38.0)

64 (43.5)

0.430

53 (43.8)

64 (43.5)

0.959

0.008

1

48 (39.7)

52 (35.4)

0.551

44 (36.4)

51 (34.7)

0.852

0.027

2

20 (16.5)

27 (18.4)

0.816

20 (16.5)

28 (19.0)

0.633

0.067

 ≥ 3

7 (5.8)

4 (2.7)

0.343

4 (3.3)

4 (2.7)

0.670

0.051

History of pulmonary Tbc

10 (8.3)

11 (7.5)

0.993

12 (9.9)

15 (10.2)

0.980

0.004

Pulmonary function

FEV1, %

87.6 ± 14.7

84.5 ± 16.2

0.109

87.4 ± 14.9

86.7 ± 16.7

0.793

0.039

DLCO, %

82.3 ± 14.2

82.6 ± 16.9

0.858

81.9 ± 14.6

82.6 ± 17.2

0.760

0.047

Tumor location

  

 < 0.001

  

0.546

0.090

Central

28 (23.1)

78 (53.4)

 

52 (43.0)

70 (47.6)

  

Peripheral

93 (76.9)

68 (46.6)

 

69 (57.0)

77 (52.4)

  

Lobar location

Right upper

32 (26.4)

45 (30.6)

0.539

38 (31.4)

46 (31.3)

0.966

0.006

Right middle

9 (7.4)

9 (6.1)

0.855

7 (5.8)

11 (7.5)

0.659

0.062

Right lower

31 (25.6)

48 (32.7)

0.262

36 (29.8)

41 (27.9)

0.806

0.036

Left upper

30 (24.8)

35 (23.8)

0.965

26 (21.5)

34 (25.0)

0.739

0.046

Left lower

19 (15.7)

10 (6.8)

0.033

14 (11.5)

15 (10.1)

0.615

0.069

Clinical tumor size, mm

29.8 ± 10.1

34.4 ± 9.1

 < 0.001

32.1 ± 10.1

32.7 ± 9.1

0.672

0.062

Histology

ADC

77 (63.6)

49 (33.3)

 < 0.001

61 (50.4)

67 (45.6)

0.522

0.095

SqCC

37 (30.6)

85 (57.8)

 < 0.001

52 (43.0)

69 (46.9)

0.587

0.081

Others

7 (5.8)

12 (8.2)

0.606

8 (6.6)

11 (7.5)

0.928

0.012

8th clinical T factor

  

 < 0.001

  

0.836

0.030

T1

46 (38.0)

20 (13.6)

 

30 (24.8)

34 (23.1)

  

T2

75 (62.0)

127 (86.4)

 

91 (75.2)

113 (76.9)

  
  1. Data are presented as number (%) unless otherwise noted. IPTW inverse probability of treatment weighting, VATS video-assisted thoracoscopic surgery, SMD standardized mean difference, FEV1 forced expiratory volume during the first second, DLCO diffusing capacity of carbon monoxide, Tbc tuberculosis, ADC adenocarcinoma, SqCC squamous cell carcinoma.
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