Figure 3
From: Endothelial dysfunction in small arteries and early signs of atherosclerosis in ApoE knockout rats
U46619 concentration–response curves of pulmonary arteries from different experimental groups under different experimental conditions; control conditions, incubation for 20 min with non-selective inhibitor of NO synthase, L-NAME (100 µM), incubation for 20 min with both L-NAME (100 µM) and indomethacin (3 µM); 20 min incubation with Cocktail: L-NAME, indomethacin, TRAM-34 and apamin, i.e. pharmacological inhibition of all major pathways for endothelium-dependent relaxation; (**), P < 0.001, effect of L-NAME; (+ +), P = 0.007, effect of indomethacin, F test, n = 8, 7.
