Figure 5 | Scientific Reports

Figure 5

From: Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions

Figure 5

Typical predictions of log10 CFU in human using only in vitro information without accounting for the clinical conversion factor (CCF) (dark grey) and in human using in vitro information and accounting for CCF (red) after hypothetical killing of (a) fast-, (b) slow- and (c) non-multiplying bacteria, and (d) combination effect including inhibition of fast-multiplying bacteria and killing of slow- and non-multiplying bacteria. The blue horizontal line illustrates a 2 log fall threshold in CFU when accounting for the CCF.

Back to article page