Table 1 Major characteristics of the participants.

From: Quantitative proteomics identifies a plasma multi-protein model for detection of hepatocellular carcinoma

Cohorts

Sample types

Groups

Sample numbers

Age, years [median (min–max)]

Sex (male/female)

HBsAg (positive/negative)

HCV antibody (positive/negative)

BCLC (A/B/C/–)

DSC (n = 10)

Tissue

HCC

10

53 (39–65)

9/1

10/0

0/10

7/1/2/0

TVC (n = 5)

HCC

5

53 (42–57)

5/0

5/0

0/5

5/0/0/0

SVC1 (n = 24)

Serum

NC

8

42 (37–54)

7/1

0/8

0/8

LC

8

40 (35–50)

8/0

8/0

0/8

HCC

8

53 (46–62)

7/1

8/0

0/8

3/2/1/2

SVC2 (n = 40)

NC

16

44 (36–55)

14/2

0/16

0/16

LC

16

41 (34–51)

13/3

16/0

0/16

HCC

8

53 (47–63)

6/2

8/0

0/8

2/2/3/1

FUC (n = 21)

HCC

21

59 (20–78)

17/4

21/0

0/21

5/14/2/0

Pa

0.08

0.17

 < 0.01

  1. BCLC Barcelona Clinic Liver Cancer stage, DSC discovery cohort, FUC follow-up cohort, HBsAg hepatitis B virus surface antigen, HCC hepatocellular carcinoma, HCV hepatitis C virus, LC liver cirrhosis, NC healthy normal control, SVC1 serum validation cohort 1, SVC2 serum validation cohort 2, TVC tissue validation cohort.
  2. – not available.
  3. aP values for the differences among different groups from different cohorts (χ2 test).