Figure 2

Transcriptomics analysis of skin lesions in ulcerative cutaneous leishmaniasis (UCL) and non UCL (NUCL) of L. tropica-infected patients, and healthy skins. (a) Partial least squares-discriminant analysis (PLS-DA) modeling was applied for classification of UCL and NUCL lesions and skin biopsies from healthy individuals. Volcano plots of UCL (b) and NUCL (c) based on DESeq2 results. Dots in red (Log FC > 1) and blue (Log FC < 1) represent differentially expressed genes with adjusted p-value < 0.05. All three figures were created using R version 3.5.1, PLS-DA with R package mixOmics 6.6.2 and volcano plots using R package ggplot2 3.2.1.