Figure 3
Common enriched GSEA pathways in the lesions of UCL and NUCL patients. Bar plot (a) and enrichment map plot (b,c) of GSEA revealed enrichment of 45 common pathways in the skin lesions of L. tropica-infected UCL and NUCL patients. In (b) and (c), dash circles denote five main clusters of enriched pathways. The color and length of the boxes represent normalized enrichment scores (NES), and the number of genes mapped to the indicated pathways, respectively. Positive and negative NES show up- and down-regulated pathways in the skin lesions of the CL patients compared with skin biopsies of healthy individuals, respectively. For the pathway analysis ReactomePA R package version 1.28.0 was used69. This package version uses Reactome version 70 (https://reactome.org/about/news/142-version-70-released). All figures were created using R version 3.5.1.
