Figure 5
Inflammatory proteins expression in the lesions of the UCL and NUCL patients compared with healthy skins. The supernatants from UCL, NUCL and healthy biopsies cultured in RPMI, were analysed using Olink Inflammation panel. (a) NPX values for proteins with significant expression (p < 0.05) in the all lesions (full squares = UCL, open squares = NUCL) relative to healthy skin (Full circles). The inflammatory proteins were categorized into: CC and CXC chemokines family, Surface Molecules and Receptors and other cytokine and inflammatory proteins. (b) Circos plot displaying the inflammatory proteins in the UCL, NUCL and healthy samples. Results were analyzed with a t test/Mann–Whitney test, and Šidák74 adjusted p-values < 0.05 were considered statistically significant. The Circos plot in (b), generated using CIRCOS v 0.69-675, visualizes the similarities and differences between UCL and NUCL patients. Red lines (p < 0.01), orange lines (p < 0.05) and yellow lines (p < 0.1).
