Table 1 Pharmacokinetic parameters of R-warfarin and S-warfarin after oral administration of warfarin (0.2 mg/kg) alone and co-administration with RVT (100 mg/kg) at 0.5 h before warfarin. Each group included 8 rats.

From: Resveratrol stereoselectively affected (±)warfarin pharmacokinetics and enhanced the anticoagulation effect

Parameter

Treatment

Warfarin alone

Warfarin + RVT

R-warfarin

  

Cmax (ng/mL)

315.1 ± 53.4

482.7 ± 49.0

AUC0−24 (h·ng/mL)

4471.1 ± 546.4

7089.3 ± 842.6*

 + 58.6%

AUC0−t (h·ng/mL)

5758.8 ± 672.0

8931.2 ± 1466.5

 + 55.1% (p = 0.07)

MRT0−t (h)

13.4 ± 1.1

11.6 ± 1.2

S-warfarin

  

Cmax (ng/mL)

489.5 ± 76.1

672.0 ± 61.0

AUC0−24 (h·ng/mL)

7128.3 ± 837.6

10,605.7 ± 829.4*

 + 48.8%

AUC0−t (h·ng/mL)

10,563.9 ± 1054.5

15,009.5 ± 1749.0*

 + 42.1%

MRT0−t (h)

17.2 ± 0.9

15.0 ± 1.0

  1. Data expressed as mean ± SEM *p < 0.05.
  2. Cmax, maximum concentration.
  3. AUC0−24, area under concentration–time curve from 0 to 24 h.
  4. AUC0−t, area under concentration–time curve to the last time.
  5. MRT0−t, mean residence time from the time of dosing to the time of last measurable concentration.
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