Figure 6
From: RNA-cDNA hybrids mediate transposition via different mechanisms
Proposed model. In wild-type cells, baseline levels of retromobility occur through the canonical integration pathway. In cells lacking both RNA–DNA hybrid and Ty1 suppressors, RNA–DNA hybrids appear to be part of a duplex nucleic acid structure and increase retromobility through the Rad52-dependent HR pathway. In contrast, in cells lacking only RNA–DNA hybrid suppressors, RNA–DNA hybrids appear to be part of triplex R-loop structures that increase retromobility through a Rad52-independent mechanism.
